Basic Information
| LncRNA/CircRNA Name | DUXAP8 |
| Synonyms | NA |
| Region | GRCh38_22:15784959-15829984 |
| Ensemble | ENSG00000206195 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | esophageal squamous cell cancer tissues, cell lines (TE-1, ESCCA109, ESC-CA9706 and KYSE520) |
| Expression Pattern | up-regulated |
| Function Description | DUXAP8 was overexpressed in ESCC tissues than that of normal adjacent tissues. DUXAP8 expression was positively correlated to tumor stage and lymph node metastasis, whereas negatively correlated to the survival rate of ESCC patients. Cell proliferation, colony formation and invasion abilities were significantly decreased after knockdown of DUXAP8 in ESCC cells. Western blot results showed that DUXAP8 could regulate the occurrence of ESCC via Wnt/?-catenin pathway. |
| Pubmed ID | 29771416 |
| Year | 2018 |
| Title | Long Non-Coding RNA DUXAP8 Regulates Proliferation and Invasion of Esophageal Squamous Cell Cancer |
External Links
| Links for DUXAP8 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |