Basic Information
| LncRNA/CircRNA Name | DUXAP10 |
| Synonyms | PCAN-3 |
| Region | GRCh38_14:19294785-19337674 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | human PCa cell lines (PC3, 22RV1, and DU145) |
| Expression Pattern | down-regulated |
| Function Description | Results showed that the expression of DUXAP10 was higher in PC3 and DU145 cell lines than that in the 22RV1 cell line. Additionally, the knockdown of DUXAP10 could remarkably inhibit the proliferation, migration, and induce apoptosis of prostate cancer cells, and significantly increase the number of G0/G1 cells in PC3 and DU145 cell lines. Moreover, DUXAP10 could promote the development of prostate cancer by regulating the process of epithelial-mesenchymal transition (EMT).The findings of this study suggested that the down-regulation of DUXAP10 expression suppressed the progression of prostate cancer by inhibiting cell proliferation, migration and promote cell apoptosis. |
| Pubmed ID | 31114994 |
| Year | 2019 |
| Title | Long Non-Coding RNA DUXAP10 Promotes the Proliferation, Migration, and Inhibits Apoptosis of Prostate Cancer Cells |
External Links
| Links for DUXAP10 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |