Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | ovarian cancer tissues ,ovarian cancer cell lines(A2780, TOV112D, HO-8910, OVCAR-3 and SKOV3) , a normal ovarian cell (ISOE80) ,293T cell |
| Expression Pattern | up-regulated |
| Function Description | DSCAM-AS1 expression was remarkably upregulated in tumor tissues compared with that in the adjacent normal tissues. Besides, ovarian cancer proliferation, migration and invasion were promoted after overexpression of DSCAM-AS1 in vitro. Moreover, after overexpression of DSCAM-AS1, SOX4 was upregulated at mRNA and protein level in vitro. Furthermore, the expression of SOX4 in tumor tissues was positively correlated with the expression of DSCAM-AS1. |
| Pubmed ID | 31173284 |
| Year | 2019 |
| Title | Long Non-Coding RNA DSCAM-AS1 Indicates a Poor Prognosis and Modulates Cell Proliferation, Migration and Invasion in Ovarian Cancer via Upregulating SOX4 |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |