Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | NSCLC tissues,cell line (16HBE, A549, NCI-H460, H1299, L9981 and NCI-H292) |
| Expression Pattern | up-regulated |
| Function Description | FSTL3 and DSCAM-AS1 were remarkably up-regulated in NSCLC samples, and miR-122-5p was down-regulated. FSTL3 was associated with worse prognosis of NSCLC patients. FSTL3 knockdown markedly inhibited the viability, migration and invasion of NSCLCs in vitro and in vivo. |
| Pubmed ID | 32280246 |
| Year | 2020 |
| Title | Up-Regulation of FSTL3, Regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, Promotes Proliferation and Migration of Non-Small Cell Lung Cancer Cells |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |