Basic Information
| LncRNA/CircRNA Name | DREH |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HBV-associated HCC tissues, cell lines (HepG2, HepG2.2.15, Hep3B, Huh-7 and SMMC-7721) |
| Expression Pattern | down-regulated |
| Function Description | DREH was frequently downregulated in hepatitis B virus (HBV) associated HCC tissues in comparison with adjacent non-cancerous hepatic tissues, and was inversely correlated with HBx mRNA expression in HBV associated HCC. the levels of DREH were inversely correlated with hepatitis B surface antigen and tumor size in HCC tissues. The forced expression of HBx in liver cell lines resulted in a significant decrease in the expression of DREH.This decrement was significantly correlated with poor survival in HCC patients. |
| Pubmed ID | 28789433 |
| Year | 2017 |
| Title | Downregulated long non-coding RNA DREH promotes cell proliferation in hepatitis B virus-associated hepatocellular carcinoma. |
External Links
| Links for DREH | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |