Basic Information
| LncRNA/CircRNA Name | DRAIC |
| Synonyms | NA |
| Region | GRCh38_15:69463026-69843120 |
| Ensemble | ENSG00000245750 |
| Refseq | NR_026979 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RIP |
| Sample | LNCaP, PC3M and C4-2B cells,PC3M, HeLa and DRAIC KO LNCaP cells |
| Expression Pattern | down-regulated |
| Function Description | Decreased DRAIC expression predicts poor patient outcome in prostate and seven other cancers, while increased DRAIC represses growth of xenografted tumors. Here, we show that cancers with decreased DRAIC expression have increased NF-?B target gene expression.DRAIC interacted with subunits of the I?B kinase (IKK) complex to inhibit their interaction with each other, the phosphorylation of I?B?, and the activation of NF-?B. These functions of DRAIC mapped to the same fragment containing bases 701-905. |
| Pubmed ID | 31900260 |
| Year | 2020 |
| Title | Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting With IKK to Inhibit NF-?B Activation |
External Links
| Links for DRAIC | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |