Basic Information
| LncRNA/CircRNA Name | DQ786243 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | gastric tissue, cell lines (SGC7901, BGC823, MGC803) |
| Expression Pattern | up-regulated |
| Function Description | The results of the present study demonstrated that the expression of DQ786243 was significant cantly upregulated in GC tissues and cell lines compared with healthy control tissues and cells. Correlation analysis revealed a signifcant association between the expression of DQ786243 and the TNM stage, tumor size, depth of invasion and presence of lymph node metastasis in patients with GC. Furthermore, silencing the DQ786243 was demonstrated to inhibit proliferation, and impair the migration and invasion of GC cells. The present results suggested that DQ786243 may function as an oncogenic regulator via promoting the proliferation and metastasis of GC cells. Therefore, DQ786243 may have potential as a novel biomarker for the diagnosis of GC, and also be a promising candidate for the development of novel therapeutic approaches for the treatment of patients with GC. |
| Pubmed ID | 28731138 |
| Year | 2017 |
| Title | Upregulation of long non-coding RNA DQ786243 promotes the progression of gastric cancer |
External Links
| Links for DQ786243 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |