Basic Information
| LncRNA/CircRNA Name | DQ786243 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | ovarian cancer tissues, cell lines (SKOV3, OVCAR3, PEO1, A2780, HOSEPiCs) |
| Expression Pattern | up-regulated |
| Function Description | DQ786243 was specifically upregulated in ovarian cancer tissues and cell lines. Knockdown of DQ786243 inhibited the ability of cell migration, invasion, proliferation, colony formation and wound healing, whereas promoted cell apoptosis and induced G0/G1 cell cycle arresting. we demonstrated that DQ786243 could directly bind to microRNA-506 (miR-506) and downregulate its expression. knockdown of DQ786243 inhibited the epithelial to mesenchymal transition (EMT) process in ovarian cancer cells. |
| Pubmed ID | 30105876 |
| Year | 2018 |
| Title | Long noncoding RNA DQ786243 interacts with miR-506 and promotes progression of ovarian cancer through targeting cAMP responsive element binding protein 1. |
External Links
| Links for DQ786243 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |