Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | DLX6-AS1, DLX6-AS, DLX6AS, Evf-2, NCRNA00212 |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | cervical cancer tissues, immortalized cervical epithelial cell lines (NC104) and human cervical cancer cell lines(CaSki,ME-180,C-33A,SiHa and HeLa) |
| Expression Pattern | up-regulated |
| Function Description | DLX6 AS1 expression was identified to be significantly upregulated in cervical cancer tissues and cell lines by reverse transcription quantitative polymerase chain reactions. Knockdown of DLX6 AS1 inhibited cell proliferation and induced cell apoptosis. Bioinformatics analysis predicted that micro RNA (miR) 199a was a direct target of DLX6 AS1. Overexpression of miR 199a counteracted the role of DLX6 AS1 in facilitating proliferation and inhibiting apoptosis in in vitro rescue assays. The present results suggest that DLX6 AS1 acting as a sponge for miR 199a may serve a critical role in the development and progression of cervical cancer |
| Pubmed ID | 30535431 |
| Year | 2019 |
| Title | Long non-coding RNA DLX6-AS1 promotes proliferation by acting as a ceRNA targeting miR-199a in cervical cancer |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |