Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | colorectal cancer tissues, cell lines (LOVO, SW1116, SW480, HCT116, SW620 and HT29) |
| Expression Pattern | up-regulated |
| Function Description | AFAP1-AS1 that facilitates colorectal cancer, where it is upregulated. AFAP1-AS1 expression was associated with colorectal cancer patient survival. AFAP1-AS1 knockdown inhibited cell proliferation, cell cycle, and tumorigenesis in an subcutaneous mouse xenograft model system. Further data demonstrated that AFAP1-AS1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. |
| Pubmed ID | 29888110 |
| Year | 2018 |
| Title | Long Noncoding RNA AFAP1-AS1 Facilitates Tumor Growth Through Enhancer of Zeste Homolog 2 in Colorectal Cancer |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |