Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | human gastric cancer cell lines (AGS, HGC-27, SGC-7901 and BGC-823) and one normal gastric epithelial cell line (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | Firstly, we measured DLX6-AS1 expression in GC and then found the elevated level of DLX6-AS1.The silencing of DLX6-AS1 suppressed cell proliferation, migration and EMT process of GC cells. MAP4K1 was also up-regulated in GC and could be positively regulated by DLX6-AS1. Moreover, MAP4K1 down-regulation similarly inhibited GC progression. In addition, DLX6-AS1 stabilized MAP4K1 via modulating FUS. In summary, DLX6-AS1 modulated GC progression through FUS-regulated MAP4K1. |
| Pubmed ID | 31591939 |
| Year | 2019 |
| Title | DLX6-AS1 Promotes Cell Proliferation, Migration and EMT of Gastric Cancer Through FUS-regulated MAP4K1 |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |