Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | NSCLC tissues and adjacent normal tissues ,cell lines(human NSCLC A549, H1299 and 95D, and normal human epithelial BEAS-2B ) ,plasma samples |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of DLX6-AS1 were significantly increased in tumor tissues compared with in adjacent normal tissues. In addition, DLX6-AS1 was highly expressed in NSCLC cell lines compared with in BEAS-2B cells.DLX6-AS1-knockdown inhibited cell proliferation and migration in vitro.The serum DLX6-AS1 level was significantly higher in patients with NSCLC compared with in healthy controls.Additionally, the higher DLX6-AS1 expression was associated with advanced disease stage, positive lymph node metastasis and poor tumor differentiation of NSCLC.Finally, exosomal DLX6-AS1 expression was increased in patients with NSCLC compared with in healthy controls. |
| Pubmed ID | 31612030 |
| Year | 2019 |
| Title | Exosomal Long Non-Coding RNA DLX6-AS1 as a Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |