Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | EOC tissues and matched adjacent normal tissues ,EOC cell lines (IOSE80,HEY, SKOV3, and OVCAR-3) ,normal ovarian epithelial cells IOSE80. |
| Expression Pattern | up-regulated |
| Function Description | We first verified the increased expression of DLX6-AS1 in EOC patient samples and cell lines.high DLX6-AS1 was significantly associated with FIGO stage, lymph node metastasis and poor prognosis.Furthermore, DLX6-AS1 as an independent prognostic factor in EOC patients.Functionally, the down-regulation of DLX6-AS1 decreased EOC cells proliferation, migration, invasion and induced cell cycle G1/S phase arrest and cell apoptosis.Knockdown of DLX6-AS1 down-regulated Notch1, p21, and Hes1, indicating that the activity of the Notch signaling pathway was inhibited. |
| Pubmed ID | 31081076 |
| Year | 2019 |
| Title | Down-regulation of Long Noncoding RNA DLX6-AS1 Defines Good Prognosis and Inhibits Proliferation and Metastasis in Human Epithelial Ovarian Cancer Cells via Notch Signaling Pathway |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |