Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qRT-PCR |
| Sample | LSCC tissues,Hep2 (LSCC cell line) |
| Expression Pattern | up-regulated |
| Function Description | the expression level of DLX6-AS1 was upregulated in the LSCC samples compared to the noncancerous tissues. By using CCK-8 analysis, we demonstrated that knockdown expression of DLX6-AS1 suppressed the Hep2 cell growth.DLX6-AS1 knockdown inhibited the Hep2 cell cycle and invasion.DLX6-AS1 knockdown suppressed cell proliferation, cycle and invasion via regulating miR-376c expression. |
| Pubmed ID | 31814904 |
| Year | 2019 |
| Title | LncRNA DLX6-AS1 Promotes Laryngeal Squamous Cell Carcinoma Growth and Invasion Through Regulating miR-376c |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |