Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | DLX6 antisense RNA 1 |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | TC tissues,thyroid carcinoma cell lines (TPC-1, K1, SW579) and normal human thyroid cell line (Nthy-ori 3-1) |
| Expression Pattern | up-regulated |
| Function Description | DLX6-AS1 expression level in TC tissues was significantly higher than that of the corresponding normal tissues. Moreover, TC cell migration and invasion were markedly inhibited after DLX6-AS1 was knocked down in vitro. The mRNA and protein expressions of UPF1 were both remarkably up-regulated after knockdown of DLX6-AS1. Meanwhile, the expression level of UPF1 was negatively correlated with the expression of DLX6-AS1 in TC tissues. Furthermore, knockdown of DLX6-AS1 significantly inhibited tumor metastasis in vivo. |
| Pubmed ID | 31858555 |
| Year | 2019 |
| Title | Knockdown of Long Noncoding RNA DLX6-AS1 Inhibits Migration and Invasion of Thyroid Cancer Cells by Upregulating UPF1 |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |