Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | NB tissues and matched adjacent non-tumor tissues, cell lines(SK-N-SH, SH-SY5Y, SK-N-AS, and SK-N-BE(2)) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of DLX6-AS1 was significantly increased in both NB tissues and cell lines, and elevated DLX6AS1 expression was positively correlated with advanced stage and poor survival. Proliferation rate, migration and invasion ability, as well as EMT process of NB cells was inhibited after DLX6-AS1 knockdown, meanwhile, the tumor growth in vivo was impaired after DLX6-AS1 inhibition. |
| Pubmed ID | 32289431 |
| Year | 2020 |
| Title | Long non-coding RNA DLX6-AS1 regulates neuroblastoma progression by targeting YAP1 via miR-497-5p. |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |