Basic Information
| LncRNA/CircRNA Name | DLX6-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , in vitro knockdown , Luciferase reporter assay , Western blot |
| Sample | NSCLC tissues ,NSCLC cell lines (CALU3, CALU6, A549, and H1299) ,human bronchial epithelial cells (HBE) |
| Expression Pattern | up-regulated |
| Function Description | DLX6-AS1 was over-expressed in NSCLC tumor tissues and cell lines and its level of expression was found to be associated with tumor size and advanced clinical stage in patients with NSCLC. Downregulation of DLX6-AS1 inhibited cell proliferation, cell clone formation, migration, and invasion of NSCLC cells. DLX6-AS1 was found to interact with miR-27b-3p/GSPT1. DLX6-AS1 expression was negatively correlated with miR-27b-3p expression, but positively correlated with GSPT1 expression in NSCLC samples. DLX6-AS1 knockdown also effectively suppressed tumor growth in an in vivo xenograft model. |
| Pubmed ID | 31190891 |
| Year | 2019 |
| Title | LncRNA?DLX6-AS1?Promotes the Proliferation, Invasion, and Migration of Non-Small Cell Lung Cancer Cells by Targeting the?miR-27b-3p/?GSPT1?Axis |
External Links
| Links for DLX6-AS | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |