Basic Information
| LncRNA/CircRNA Name | AATBC |
| Synonyms | AATBC |
| Region | GRCh38_21:43805758-43812567 |
| Ensemble | ENSG00000215458 |
| Refseq | NR_026961 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Microarray, qPCR, RNAi, in vitro knockdown etc. |
| Sample | bladder cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We found that AATBC was overexpressed in bladder cancer patient tissues and positively correlated with tumor grade and pT stage. We also found that inhibition of AATBC resulted in cell proliferation arrest through G1 cell cycle mediated by cyclin D1, CDK4, p18 and phosphorylated Rb. In addition, inhibition of AATBC induced cell apoptosis through the intrinsic apoptosis signaling pathway, as evidenced by the activation of caspase-9 and caspase-3. The investigation for the signaling pathway revealed that the apoptosis following AATBC knockdown was mediated by activation of phosphorylated JNK and suppression of NRF2. |
| Pubmed ID | 25473900 |
| Year | 2014 |
| Title | Knockdown of a novel LincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. |
External Links
| Links for AATBC | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |