Basic Information
| LncRNA/CircRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP0 |
| Region | GRCh38_13:49982552-50125720 |
| Ensemble | ENSG00000231607 |
| Refseq | NR_002612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | osteosarcoma tissues,cell lines(Saos-2, NHOst, MG-63, 143B, and U-2OS) |
| Expression Pattern | up-regulated |
| Function Description | DLEU2 expression level was raised remarkably in comparison with that in para-carcinoma normal tissues, and DLEU2 high expression had associations with poor prognosis, tumour stages, and TS of osteosarcoma cases. Cell migration ability and viability were blocked by DLEU2 knockdown but enhanced by ectopic DLEU2 expression in vitro and in vivo. |
| Pubmed ID | 32196715 |
| Year | 2020 |
| Title | LncRNA DLEU2 Promotes Tumour Growth by Sponging miR-337-3p in Human Osteosarcoma |
External Links
| Links for DLEU2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |