Basic Information
| LncRNA/CircRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP1 |
| Region | GRCh38_13:49982552-50125720 |
| Ensemble | ENSG00000231607 |
| Refseq | NR_002612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | gastric cancer tissues, cell lines (BGC823 and MKN45) |
| Expression Pattern | up-regulated |
| Function Description | DLEU2 and DDX11-AS1were significantly upregulated in GC tissues, promote GC cell proliferation, and negatively regulate miRNA expression, respectively. Knockdown of DLEU2 and DDX11-AS1 suppressed cell proliferation in BGC823 and MKN45 cells, as determined by CCK-8 assays. By using qRT-PCR, we observed that knockdown of DLEU2 and DDX11-AS1 significantly increased the hsa-miR-30-5p and hsa-miR-145-5p expression level, respectively. |
| Pubmed ID | 29912172 |
| Year | 2018 |
| Title | Integrative Analysis of Dysregulated lncRNA-Associated ceRNA Network Reveals Functional lncRNAs in Gastric Cancer |
External Links
| Links for DLEU2 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |