Basic Information
| LncRNA/CircRNA Name | DLEU1 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 |
| Region | GRCh38_13:50082171-50723236 |
| Ensemble | ENSG00000176124 |
| Refseq | NR_002605 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, ChIP, Luciferase reporter assay etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | In contrast, the lncRNA genes DLEU1 and variant DLEU2/Alt1 that display DNA-hypomethylation at their 5' ends are significantly upregulated in CLL cells. We found a significant inverse correlation of gene expression of the lncRNA genes DLEU1 and the DLEU2 variant Alt1 with DNA-methylation levels in regions D6 and E6 that are localized at their transcriptional start sites. |
| Pubmed ID | 23593011 |
| Year | 2013 |
| Title | Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. |
External Links
| Links for DLEU1 | GenBank HGNC NONCODE |
| Links for chronic lymphocytic leukemia | OMIM COSMIC |