Basic Information
| LncRNA/CircRNA Name | DLEU1 |
| Synonyms | NA |
| Region | GRCh38_13:50082171-50723236 |
| Ensemble | ENSG00000176124 |
| Refseq | NR_002605 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | Microarray, qPCR, Western blot |
| Sample | oral squamous cell carcinoma tissues, cell line |
| Expression Pattern | up-regulated |
| Function Description | we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. A recent study showed that expression of DLEU1 is upregulated via DNA demethylation in CLL, and that epigenetic aberration is associated with downregulation of neighboring tumor suppressor genes that regulate NF-?B signaling. These results suggest that DLEU1 contributes to OSCC progression by promoting proliferation, migration, and invasion by OSCC cells and by inhibiting apoptosis. |
| Pubmed ID | 30069008 |
| Year | 2018 |
| Title | Screening for Long Noncoding RNAs Associated With Oral Squamous Cell Carcinoma Reveals the Potentially Oncogenic Actions of DLEU1. |
External Links
| Links for DLEU1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |