Basic Information
| LncRNA/CircRNA Name | DIRC3 |
| Synonyms | Disrupted In Renal Carcinoma 3 |
| Region | NA |
| Ensemble | ENSG00000231672 |
| Refseq | NR_026597 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blotting, RNA-seq |
| Sample | 501mel, SK-MEL-28 and A375 human melanoma cells |
| Expression Pattern | down-regulated |
| Function Description | DIRC3 depletion in human melanoma cells leads to increased anchorage-independent growth, a hallmark of malignant transformation, whilst melanoma patients classified by low DIRC3 expression have decreased survival. DIRC3 is a nuclear lncRNA that activates expression of its neighbouring IGFBP5 tumour suppressor through modulating chromatin structure and suppressing SOX10 binding to putative regulatory elements within the DIRC3 locus. |
| Pubmed ID | 31881017 |
| Year | 2019 |
| Title | The MITF-SOX10 Regulated Long Non-Coding RNA DIRC3 Is a Melanoma Tumour Suppressor |
External Links
| Links for DIRC3 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |