Basic Information
| LncRNA/CircRNA Name | DIO3OS |
| Synonyms | NA |
| Region | GRCh38_14:101552221-101560431 |
| Ensemble | ENSG00000258498 |
| Refseq | NR_002770 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | Human PC cell lines (AsPC-1, MIA PaCa-2, PANC-1 and BxPC-1), human pancreatic duct epithelial cell line HPDE6-C7, PC tissues, normal tissues, PC tissues, normal tissues |
| Expression Pattern | up-regulated |
| Function Description | DIO3OS was highly expressed in human PC tissues and PC cell lines. DIO3OS exhibited oncogenic properties in stimulating PC cell proliferation and invasion in vitro and promoting cancer growth in vivo. Through online predictive tools and functional experiments, we found that DIO3OS could bind directly to microRNA-122 (miR-122) and inhibited its expression, which functioned as a tumor suppressor in PC cells. We also verifed that ALDOA was the direct target of miR-122, and the tumor suppressive efects caused by DIO3OS knockdown or miR-122 overexpression could be rescued by re-expression of ALDOA in PC cells. |
| Pubmed ID | 31384177 |
| Year | 2019 |
| Title | Long noncoding RNA DIO3OS interacts with miR-122 to promote proliferation and invasion of pancreatic cancer cells through upregulating ALDOA |
External Links
| Links for DIO3OS | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |