Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | DGCR5, LINC00037, NCRNA00037 |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | LC tissues, cell ines (BEAS-2B, H520, H157, SKMES1, H460, A549, H1299, HEK293T) |
| Expression Pattern | down-regulated |
| Function Description | DGCR5 was downregulated and miR-1180 was upregulated in the sera and tissues of LC patients and was correlated with poor prognosis. a negative correlation between the expression of DGCR5 and miR-1180 in LC tissues and sera. DGCR5 negatively regulated miR-1180 expression. DGCR5 suppressed the proliferation, migration and invasion of LC cells by targeting miR-1180.Recently, a novel lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) was found to be downregulated in hepatocellular carcinoma (HCC), and low expression of DGCR5 was closely associated with poor five-year survival rate. |
| Pubmed ID | 28744397 |
| Year | 2017 |
| Title | Long non-coding RNA DGCR5 is involved in the regulation of proliferation, migration and invasion of lung cancer by targeting miR-1180. |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |