Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | NA |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | NSCLC cells (A549 and H1299), normal cell line (16HBE) |
| Expression Pattern | down-regulated |
| Function Description | RT-qPCR revealed that DGCR5 expression in NSCLC cells was significantly lower than in normal cell. DGCR5 overexpression suppresses NSCLC cell growth, migration, and invasion. Online algorithms found EPH receptor B6 (EPHB6) and DGCR5 contains same miR-211-5p binding region. The predicted connections were further validated by luciferase activity reporter assay. Recue experiments showed DGCR5 regulates NSCLC cell behaviors via targeting miR-211-5p/EPHB6. |
| Pubmed ID | 31241800 |
| Year | 2019 |
| Title | LncRNA DGCR5 regulates the non small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |