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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	GC tissues, human GC cell lines SGC-7901, MGC-803, HGC-27, and AGS,human normal gastric epithelial cell line GES-1,Human embryonic kidney (HEK)-293T
Expression Pattern	down-regulated
Function Description	demonstrated that DGCR5 was downregulated in cancerous tissues and plasma samples from patients with GC, and its downregulation was associated with advanced TNM stage and positive lymphatic metastasis. Plasma DGCR5 had an area under the receiver operating characteristic curve (AUC) of 0.722 for diagnosis of GC. Gain and loss of function of DGCR5 revealed that DGCR5 functioned as a competing endogenous RNA for miR 23b to suppress GC cell proliferation, invasion and migration, and facilitate apoptosis by regulating PTEN and BTG1 in vitro. Furthermore, the overexpression of DGCR5 suppressed tumor growth, and inhibited the expression of miR 23b and proliferation antigen Ki 67, but increased the expression of PTEN and BTG1 in vivo. In conclusion, our results show that DGCR5 is a tumor suppressive lncRNA that regulates PTEN and BTG1 expression through directly binding to miR 23b.
Pubmed ID	30515803
Year	2018
Title	Long noncoding RNA DGCR5 suppresses gastric cancer progression by acting as a competing endogenous RNA of PTEN and BTG1

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