Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | DGCR5, LINC00037, NCRNA00037 |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, other |
| Sample | CRC tissues and cell lines (RKO, CR4) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of DGCR5 in tumor tissue decreased, while expression levels of miR-21 increased, with advancing stages of the disease. The expression levels of DGCR5 and miR-21 were inversely associated in tumor tissues. In CRC cells in vitro, miR-21 overexpression failed to significantly affect DGCR5, while DGCR5 overexpression resulted in reduced expression levels of miR-21. DGCR5 overexpression showed no significant effects on cancer cell migration and invasion, but suppressed cancer cell proliferation in vitro. miR-21 overexpression increased cancer cell proliferation and attenuated the effects of DGCR5 overexpression. |
| Pubmed ID | 31452812 |
| Year | 2019 |
| Title | lncRNA DGCR5 Inhibits the Proliferation of Colorectal Cancer Cells by Downregulating miR-21 |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |