Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | DGCR5, LINC00037, NCRNA00037 |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, other |
| Sample | HCC tissues and cel lines (HepG2, Hep3B, MHCC-97L, SNU-449, SNU-182, and LO2) |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of DGCR5 was able to restrain HCC growth, migration, and invasion capacity in HepG2 and SNU-449 cells. In addition, whether lncRNA-DGCR5 can regulate Wnt/?-catenin pathway during HCC progression is unclear. In our study, it was found that upregulation of DGCR5 inactivated Wnt signaling pathway through inhibiting ?-catenin, cyclin D1 and increasing GSK-3? levels. Subsequently, in vivo tumor xenografts were established using HepG2 cells to investigate the function of DGCR5 in HCC development. Inconsistent with the in vitro findings, increase of DGCR5 dramatically suppressed HCC tumor progression in vivo. |
| Pubmed ID | 30230592 |
| Year | 2019 |
| Title | Long Noncoding RNA DGCR5 Represses Hepatocellular Carcinoma Progression by Inactivating Wnt Signaling Pathway |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |