Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | DiGeorge syndrome critical region gene 5 |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma multiforme |
| ICD-0-3 | NA |
| Methods | qRT-PCR |
| Sample | glioblastoma tissue,glioblastoma cells (LN229, A172, U251, and U87) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA DGCR5 was down expressed in glioblastoma. Transfection of DGCR5 markedly repressed cell viability and colony formation ability of U87 and U251 cells. Additional, DGCR5 overexpression caused cell cycle arrest and increased cell apoptosis. Moreover, upregulation of DGCR5 suppressed the growth and promoted cell apoptosis of U87 cell in vivo. Finally, overexpression of DGCR5 impaired the migration, invasiveness, and reversed epithelial-to-mesenchymal transition (EMT) process of glioblastoma cell. |
| Pubmed ID | 31799672 |
| Year | 2019 |
| Title | DGCR5 Suppresses the EMT of Pediatric Primary Glioblastoma Multiforme Cell and Serves as a Prognostic Biomarker |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for glioblastoma multiforme | OMIM COSMIC |