Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | NA |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, RIP etc |
| Sample | NSCLC tissues, cell lines (SPCA1, H1299, PC-9, and H358) |
| Expression Pattern | up-regulated |
| Function Description | DGCR5 was remarkably highly expressed in NSCLC tissues compared to that of adjacent normal tissues. The migration and invasion of NSCLC cells were significantly promoted via overexpression of DGCR5. However, the silence of DGCR5 significantly inhibited NSCLC cell migration and invasion. |
| Pubmed ID | 31799664 |
| Year | 2019 |
| Title | DGCR5 was remarkably highly expressed in NSCLC tissues compared to that of adjacent normal tissues. The migration and invasion of NSCLC cells were significantly promoted via overexpression of DGCR5. However, the silence of DGCR5 significantly inhibited NSCLC cell migration and invasion. |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |