Basic Information
| LncRNA/CircRNA Name | DDX11-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:31020763-31073847 |
| Ensemble | ENSG00000245614 |
| Refseq | NR_038927 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , RIP , RNAi , in vitro knockdown etc. |
| Sample | HCC and corresponding adjacent normal liver tissues ,HCC cell lines (HepG2, SMMC-7721, SK-hep1, Huh7, and HCCLM3) and normal hepatic cell line LO2 |
| Expression Pattern | up-regulated |
| Function Description | DDX11-AS1 expression was dramatically higher in HCC tissues and cell lines. Higher DDX11-AS1 expression predicted poor overall survival of patients.Functionally, the proliferation, cell cycle progression, migration, and invasion of HCC cells were inhibited by DDX11-AS1 silencing, while promoted by ectopic expression of DDX11-AS1.DDX11-AS1 suppressed LATS2 expression by interacting with EZH2 and DNMT1 in HCC cells. Knockdown of DDX11-AS1 increased the mRNA and protein levels of LATS2. Overexpression of LATS2 abolished the promotive effect of DDX11-AS1 on cell growth and invasion. Besides, DDX11-AS1 promoted tumor formation in vivo.The mRNA levels of LATS2 were markedly decreased in tumor tissues and negatively correlated with DDX11-AS1 expression. |
| Pubmed ID | 31097223 |
| Year | 2019 |
| Title | Long Noncoding RNA DDX11-AS1 Epigenetically Represses LATS2 by Interacting With EZH2 and DNMT1 in Hepatocellular Carcinoma |
External Links
| Links for DDX11-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |