Basic Information
| LncRNA/CircRNA Name | DDX11-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:31020763-31073847 |
| Ensemble | ENSG00000245614 |
| Refseq | NR_038927 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Oxaliplatin (OXA) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | GC tissues,cell lines(MKN45 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | DDX11-AS1 was overexpressed in OXA-resistant GC tissues and cells, and DDX11-AS1 knockdown inhibited cell proliferation, migration, invasion and OXA resistance, and promoted apoptosis in OXA-resistant GC cells.Mechanically, DDX11-AS1 directly targeted miR-326 and miR-326 could bind to IRS1 in OXA-resistant GC cells. |
| Pubmed ID | 32271422 |
| Year | 2020 |
| Title | The Long Non-Coding RNA DDX11-AS1 Facilitates Cell Progression and Oxaliplatin Resistance via Regulating miR-326/IRS1 Axis in Gastric Cancer |
External Links
| Links for DDX11-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |