Basic Information
| LncRNA/CircRNA Name | AATBC |
| Synonyms | LOC284837 |
| Region | GRCh38_21:43805758-43812567 |
| Ensemble | ENSG00000215458 |
| Refseq | NR_026961 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | Western blot, qRT-PCR, Luciferase reporter assay etc. |
| Sample | NPC tissues and NPE tissues,cell lines (5-8F, HNE2, and CNE2) |
| Expression Pattern | up-regulated |
| Function Description | AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. AATBC promotes NPC progression through the miR-1237-3p-PNN-ZEB1 axis. Our findings indicate AATBC as a potential prognostic biomarker or therapeutic target in NPC. |
| Pubmed ID | 32364663 |
| Year | 2020 |
| Title | LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. |
External Links
| Links for AATBC | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |