Basic Information
| LncRNA/CircRNA Name | DBCCR1-003 |
| Synonyms | BRINP1, DBC1, DBCCR1, FAM5A |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, MSP-PCR, Western blot, RIP, ChIP, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | bladder cancer tissues, cell lines (T24, SV-HUC-1) |
| Expression Pattern | down-regulated |
| Function Description | We found low expression of DBCCR1-003, same as DBCCR1, while high expression of DNMT1 and hypermethylation of DBCCR1 gene promoter in BC tissues and T24 cells line. The binding of them was increased with the inhibition of DBCCR1 promoter methylation, indicating that DBCCR1-003 may bind to DNMT1 and prevent DNMT1-mediated the methylation of DBCCR1. Furthermore, overexpression of DBCCR1-003 resulted in significant inhibition of T24 cells growth through the inducing G0/G1 arrest and apoptosis. |
| Pubmed ID | 27777512 |
| Year | 2016 |
| Title | Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer. |
External Links
| Links for DBCCR1-003 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |