Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioblastoma tissue, cell lines (U87, U251, SGC7901 and BGC823) |
| Expression Pattern | up-regulated |
| Function Description | High expression of DANCR might be a poor prognostic factor in glioma patients. Results of loss-of function assay suggested that downregulated DANCR could inhibited glioma cell proliferation and migration. Additionally, western blot assay was conducted in glioma cells to demonstrate that the protein levels of the Wnt/B-catenin pathway related proteins was negatively modulated by si-DANCR. Finally, and the increased proliferation and migration of glioma cells were observed after the Wnt/B-catenin signals were activated. However, this tendency was reduced by si-DANCR. |
| Pubmed ID | 29602127 |
| Year | 2018 |
| Title | Overexpression of lncRNA DANCR positively affects progression of glioma via activating Wnt/B-catenin signaling. |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |