Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | glioma tissues, glioma cell lines (U251, U118, LN229, and U87MG) |
| Expression Pattern | up-regulated |
| Function Description | DANCR was significantly up-regulated in glioma tissues and cell lines (U251, U118, LN229, and U87MG). High DANCR expression was correlated with advanced tumor grade.Inhibition of DANCR suppressed the glioma cells proliferation and induced cells arrested in the G0/G1 phase.In addition,we verified that DANCR could directly interact with miR-634 in glioma cells and this interaction resulted in the inhibition of downstream of RAB1A expression. |
| Pubmed ID | 29301870 |
| Year | 2018 |
| Title | LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma. |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |