Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SPC-A, NCL-H1650, NCL-H1975, SK-MES-1, A549, NCL-H358 and NCI-H1299, 16HBE), NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | DANCR was markedly upregulated in NSCLC tumor tissues and cell lines compared with related normal controls.The ectopic expression of DANCR significantly increased the proliferation, migration and invasion of SPC-A1 and NCL-H1299 cells. Furthermore, we investigated whether DANCR regulates NSCLC tumor formation in vivo. Subsequently, we concluded that DANCR promotes NSCLC cell proliferation, migration and invasion by regulating the tumor suppressor miR-758-3p.the DANCR/miR-758-3p axis could be a potential target in the treatment of NSCLC. |
| Pubmed ID | 29635134 |
| Year | 2018 |
| Title | The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p. |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |