Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP, etc. |
| Sample | freshly frozen normal nasopharyngeal epithelial tissues and NPC biopsy tissues, Human NPC cell lines (SUNE-1, HONE-1, CNE-1, CNE-2, HNE-1, 5-8F, 6-10B and C666-1) |
| Expression Pattern | up-regulated |
| Function Description | DANCR was upregulated in NPC, especially in those with lymph lode metastasis, and its upregulation could predict poor survival. We then constructed a prognostic predictive model. RNA sequencing followed by bioinformatic analysis revealed that DANCR was responsible for NPC metastasis and hypoxia phenotype. Functional studies showed that DANCR promoted NPC cell invasion and metastasis in vitro and in vivo. Further investigation suggested that DANCR could increase HIF-1? mRNA stability through interacting with the NF90/NF45 complex. Additionally, overexpression of HIF-1? in DANCR knockdown cells restored its suppressive effects on NPC cell migration and invasion. |
| Pubmed ID | 30555573 |
| Year | 2018 |
| Title | Long Non-Coding RNA DANCR Stabilizes HIF-1? and Promotes Metastasis by Interacting With NF90/NF45 Complex in Nasopharyngeal Carcinoma |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |