Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, other |
| Sample | HCC tissues and cell lines(Hep3B, HepG2, Huh7, SNU449, SK-hep-1, and LO2 ) |
| Expression Pattern | up-regulated |
| Function Description | HCC cell apoptosis was increased by silence of DANCR and meanwhile, cell cycle progression was blocked in G1 phase. Apart from these, downregulation of DANCR repressed HCC cell migration and invasion ability obviously. As predicted by the bioinformatics analysis, microRNA-216a-5p (miR-216a-5p) could serve as a direct target of DANCR. MiR-216a-5p has been reported to be involved in many cancers. Here, the correlation between miR-216a-5p and DANCR was confirmed using dual-luciferase reporter assay and radioimmunoprecipitation assay. |
| Pubmed ID | 30430564 |
| Year | 2019 |
| Title | DANCR Contributed to Hepatocellular Carcinoma Malignancy via Sponging miR-216a-5p and Modulating KLF12 |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |