Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hepatocellular Carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown, RIP etc. |
| Sample | All human HCC cells involved and immortalized human hepatic cell LO2 |
| Expression Pattern | up-regulated |
| Function Description | The high expression of DANCR in HCC. DANCR accelerated proliferation and metastasis of HCC cells and the knockdown of DANCR had the opposite effect. Meanwhile, xenograft tumours in sh-DANCR group grow slower and have smaller volumes compared with negative control group. Next, the antineoplastic effect of miR-27a-3p on cell growth and motility of HCC was confirmed. In addition, we clarified that DANCR acted as a ceRNA to decoy miR-27a-3p via mediating ROCK1/LIMK1/COFILIN1 pathway. In the end, we validated that DANCR/miR-27a-3p axis regulates EMT progression by cell immunofluorescence and Western blot. |
| Pubmed ID | 31038266 |
| Year | 2019 |
| Title | DANCR Promotes HCC Progression and Regulates EMT by Sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 Pathway |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for Hepatocellular Carcinoma | OMIM COSMIC |