Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin(DDP) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | DDP-sensitive GC tissues and cases of DDP-resistant GC tissues ,GC cell lines(SGC7901 and BGC823) |
| Expression Pattern | up-regulated |
| Function Description | DANCR expression remained high in DDP-resistant GC tissues or cells. SGC7901/DDP and BGC823/DDP cells transfected with si-DANCR presented decreased survival and increased apoptosis.On the contrary, SGC7901/DDP and BGC823/DDP cells overexpressing DANCR showed increased survival and decreased apoptosis. In addition, DANCR overexpression could upregulate expressions of MDR1 and MRP1 in DDP-induced SGC901 and BGC823 cells. |
| Pubmed ID | 31002130 |
| Year | 2019 |
| Title | LncRNA DANCR Accelerates the Development of Multidrug Resistance of Gastric Cancer |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |