Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | ovarian cancer tissues and adjacent tissues,ovarian cancer cell lines (A2780, TOV112D, OVCAR-3 and SKOV3) ,normal ovarian cell line (ISOE80) |
| Expression Pattern | up-regulated |
| Function Description | The expression of DANCR in ovarian cancer samples was significantly higher than that of the corresponding normal tissues. After DANCR overexpression in vitro, the proliferation, invasion and migration of ovarian cancer cells were markedly promoted. In addition, both the mRNA and protein expression levels of insulin-like growth factor 2 (IGF2) were remarkably upregulated after DANCR overexpression. Furthermore, the results found that the expression level of IGF2 was positively correlated with DANCR expression in ovarian cancer tissues. |
| Pubmed ID | 31114986 |
| Year | 2019 |
| Title | Long Non-Coding RNA DANCR Upregulates IGF2 Expression and Promotes Ovarian Cancer Progression |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |