Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | EC tissues and normal control endometrial tissues ,Human EC cell lines(KLE, RL95-2, ishikawa,AN3CA, and HEC-1B) |
| Expression Pattern | up-regulated |
| Function Description | DANCR expression was up-regulated in EC tissues as compared to the normal control tissues.Knockdown of DANCR in AN3CA and HEC-1B cells markedly suppressed cell proliferation and induced cell apoptosis.miR-214 was found to be a target miRNA of DANCR and its expression was significantly decreased in EC tissues.Suppression of miR-214 abolished the effects of si-DANCR on cell proliferation and apoptosis in AN3CA and HEC-1B cells. DANCR played an important role in promoting tumorigenesis of EC via sponging miR-214. |
| Pubmed ID | 31161373 |
| Year | 2019 |
| Title | Knockdown of Differentiation Antagonizing Non-Protein Coding RNA Exerts Anti-Tumor Effect by Up-Regulating miR-214 in Endometrial Carcinoma |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |