Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | differentiation antagonizing non-protein coding RNA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qRT-PCR, Luciferase reporter assay, Western blot |
| Sample | TSCC cell lines (SCC9, TSCCA, TCa-8113 and CAL-27 cells) |
| Expression Pattern | up-regulated |
| Function Description | DANCR knockdown reduced the viability and inhibited the migration and invasion of TSCC cells in vitro, while ectopic expression of DANCR induced opposite effects. In vivo, the tumor growth and the expression of matrix metalloproteinase (MMP)-2/9 and KLF8 were also blocked by DANCR inhibition. |
| Pubmed ID | 31827393 |
| Year | 2019 |
| Title | LncRNA DANCR Promotes the Proliferation, Migration, and Invasion of Tongue Squamous Cell Carcinoma Cells Through miR-135a-5p/KLF8 Axis |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |