Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, RIP |
| Sample | OC tissues,Epithelial ovarian cell line (IOSE-386) and OC cell lines (SKOV-3, OVCAR3, HO8910, and HEY) |
| Expression Pattern | up-regulated |
| Function Description | DANCR was upregulated in OC tissues and cell lines. Its level was higher in OC patients with worse tumor stage and accompanied by metastatic loci. DANCR exerted the potential to serve as a prognostic marker for OC. Overexpression of DANCR accelerated HO8910 and HEY cells to proliferate and migrate.DANCR was mainly distributed in the cytoplasm and interacted with UPF1. |
| Pubmed ID | 31858532 |
| Year | 2019 |
| Title | LncRNA DANCR Aggravates the Progression of Ovarian Cancer by Downregulating UPF1 |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |