Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | differentiation antagonizing non-protein coding RNA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western immunoblots, RIP |
| Sample | breast cancer tissues,breast epithelial cell line MCF10A, and breast cancer cell lines MCF7, T47D, MDA-MB-231, and MDA-MB-468 |
| Expression Pattern | up-regulated |
| Function Description | DANCR was significantly up-regulated in tissue samples from patients with breast cancer, as well as in breast cancer cell lines, as compared with normal tissues and breast epithelial cells, respectively. The highest DANCR expression levels were associated with advanced tumor grades or lymph node metastasis. DANCR was necessary and sufficient to control multiple malignant phenotypes of breast cancer cells in vitro and xenograft growth in vivo. Mechanistically, DANCR promoted the binding of enhancer of zeste homolog 2 (EZH2) to the promoter of SOCS3, thereby epigenetically inhibiting SOCS3 expression. |
| Pubmed ID | 31860165 |
| Year | 2020 |
| Title | The Long Non-Coding RNA DANCR Regulates the Inflammatory Phenotype of Breast Cancer Cells and Promotes Breast Cancer Progression via EZH2-dependent Suppression of SOCS3 Transcription |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |