Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | Differentiation antagonizing non-protein coding RNA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, RIP, Western blotting analysis |
| Sample | colorectal cancer samples,colorectal cancer cell lines (LOVO, SW480, HCT116, SW620, and HT29 ),NCM460 cells |
| Expression Pattern | up-regulated |
| Function Description | DANCR, which was upregulated in colorectal cancer. The upregulation of DANCR expression was associated with shorter patient survival time. DANCR depletion decreased cell proliferation, cell cycle progression, and tumorigenesis in a subcutaneous mouse xenograft model system. We further demonstrated that DANCR bound with lysine acetyltransferase 6A. This binding was essential for KAT6A acetyltransferase activity and thus, it influenced the expression of KAT6A target genes. |
| Pubmed ID | 31863900 |
| Year | 2020 |
| Title | Long Non-Coding RNA DANCR Promotes Colorectal Tumor Growth by Binding to Lysine Acetyltransferase 6A |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |