Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, luciferase reporter assay etc |
| Sample | CAA tissues,cell lines (HuH28, HuCCT1 and SG231) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of DANCR was significantly induced in CCA tissues and cells. Inhibition of DANCR remarkably suppressed CCA cell proliferation, migration, invasion, EMT and angiogenesis as well as induced cell apoptosis in vitro and in vivo. Luciferase reporter assay determined that DANCR directly targeted miR-345-5p and Twist1 was a target mRNA of miR-345-5p. Otherwise, miR-345-5p down-expression partially reversed the effect induced by the suppression of DANCR in CCA. |
| Pubmed ID | 32196584 |
| Year | 2020 |
| Title | LncRNA DANCR Affected Cell Growth, EMT and Angiogenesis by Sponging miR-345-5p Through Modulating Twist1 in Cholangiocarcinoma |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |