Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blot |
| Sample | cervical cancer tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | enhanced expression of DANCR promotes cervical cancer cell proliferation in vitro and xenograft growth in vivo. Conversely, DANCR knockdown inhibits cervical cancer cell proliferation in vitro and xenograft growth in vivo. Mechanistic investigation demonstrated that DANCR upregulates the expressions of FRAT1 and FRAT2 and activates the Wnt/?-catenin signaling pathway. DANCR as an oncogenic lncRNA in cervical cancer through activating the Wnt/?-catenin signaling pathway |
| Pubmed ID | 32123519 |
| Year | 2020 |
| Title | Long non-coding RNA DANCR promotes cervical cancer growth via?activation of?the?Wnt/?-catenin signaling pathway |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |